Tom's Of Maine Fluoride-Free Rapid Relief Sensitive Toothpaste Fresh Mint 4oz uses a powerful combination of arginine and calcium carbonate — both derived from natural sources — to seal the pathways to sensitive tooth nerves to help block the pain. Our patented, clinically proven formula provides relief in 60 seconds* and long-lasting protection with continuous use. *This patented formula provides rapid relief when directly applied to the sensitive tooth with fingertip and gently massaged for 1 minute.